PSORIASIS

VITAMIN D
(1 microgram = 0.001 milligrams)

1. Daily treatment with tacalcitol (vitamin D) ointment (20 micrograms per gram) for 12 weeks improved redness, thickness and scaling in psoriasis vulgaris that was not responsive to corticosteroid treatment.

Eur J Dermatol. 2002 Nov-Dec;12(6):553-7. 
High-concentration (20 mug/g) tacalcitol ointment therapy on refractory psoriasis vulgaris with low response to topical corticosteroids.
Katayama I, Ohkawara A, Ohkido M, Harada S, Tamaki K, Nakagawa H, Hori Y, Nishiyama S.
PMID: 12459526

2. Daily treatment with tacalcitol (vitamin D) ointment (4 micrograms per gram) for 18 months reduced the severity of plaque psoriasis.

Br J Dermatol. 2002 Mar;146(3):414-22. 
Long-term efficacy and safety of tacalcitol ointment in patients with chronic plaque psoriasis.
van de Kerkhof PC, Berth-Jones J, Griffiths CE, Harrison PV, Honigsmann H, Marks R, Roelandts R, Schopf E, Trompke C.
PMID: 11952541

3. Daily treatment of plaque psoriasis with calcitriol (vitamin D) ointment (3 micrograms per gram) was less irritating than treatment with tacalcitol or petroleum.

Eur J Dermatol. 2001 May-Jun;11(3):219-24. 
The safety of calcitriol 3 microg/g ointment. Evaluation of cutaneous contact sensitization, cumulative irritancy, photoallergic contact sensitization and phototoxicity.
Queille-Roussel C, Duteil L, Parneix-Spake A, Arsonnaud S, Rizova E.
PMID: 11358728

4. This review indicates that daily treatment of plaque psoriasis with calcitriol (vitamin D) ointment (3 micrograms per gram) is safe and effective.

Br J Dermatol. 2001 Apr;144 Suppl 58:11-6. 
Efficacy and tolerance of topical calcitriol 3 microg g(-1) in psoriasis treatment: a review of our experience in Poland.
Langner A, Stapor W, Ambroziak M.
PMID: 11501507

5. Daily treatment of chronic plaque psoriasis with calcitriol (vitamin D) ointment (3 micrograms per gram) twice/day is safe and effective in treating lesions.

Br J Dermatol. 2001 Apr;144 Suppl 58:17-9. 
Long-term safety of topical calcitriol 3 microg g(-1) ointment.
Gerritsen MJ, Van De Kerkhof PC, Langner A.
PMID: 11501508

6. This review indicates that daily treatment with calcitriol (vitamin D) ointment (3 micrograms per gram) is safe and effective in treating psoriasis of the head.

Br J Dermatol. 2001 Apr;144 Suppl 58:21-5. 
Clinical experience with topical calcitriol (1,25-dihydroxyvitamin D3) in psoriasis.
Kowalzick L.
PMID: 11501509

7. Daily treatment of chronic plaque psoriasis with calcitriol (vitamin D) ointment (3 micrograms per gram) is the minimum dose that is effective and it is without side effects.

Br J Dermatol. 2001 Apr;144 Suppl 58:3-10. 
Topical calcitriol--studies on local tolerance and systemic safety.
Rizova E, Corroller M.
PMID: 11501511

8. This review suggests that treatment of chronic plaque psoriasis with calcipotriol (vitamin D analog) ointment (50 micrograms per gram) twice/day is more effective than other anti-psoriasis treatments.

Am J Clin Dermatol. 2001;2(2):95-120. 
Calcipotriol ointment. A review of its use in the management of psoriasis.
Scott LJ, Dunn CJ, Goa KL.
PMID: 11705309

9. Treatment of palmoplantar psoriasis with calcipotriol (vitamin D analog) ointment (50 micrograms per mg) twice/day was more effective than twice/weekly application.

Int J Tissue React. 2001;23(2):59-62. 
Occlusive versus nonocclusive calcipotriol ointment treatment for palmoplantar psoriasis.
Duweb GA, Abuzariba O, Rahim M, al-Taweel M, al-Alem S, Abdulla SA.
PMID: 11447774

10. Daily application of tacalcitol (vitamin D) ointment (4 micrograms per gram) is effective and safe treatment for chronic plaque psoriasis.

Hosp Med. 2000 Jun;61(6):402-5. 
Topical tacalcitol treatment for psoriasis.
Harrison PV.
PMID: 10962655

11. Daily treatment of psoriasis with tacalcitol (vitamin D) ointment (4 micrograms per gram) effectively reduces redness and scaling without side effect.

Curr Med Res Opin. 1998;14(4):213-8. 
Current experience with tacalcitol ointment in the treatment of psoriasis.
Gollnick H, Menke T.
PMID: 9891193

12. Daily treatment of psoriasis with tacalcitol ointment (4 micrograms per gram/day) is nearly as effective as calcipotriol (vitamin D analog) ointment (50 micrograms per mg) twice/day.

Br J Dermatol. 1997 Oct;137(4):581-6. 
Once daily treatment of psoriasis with tacalcitol compared with twice daily treatment with calcipotriol. A double-blind trial.
Veien NK, Bjerke JR, Rossmann-Ringdahl I, Jakobsen HB.
PMID: 9390335

13. Treatment of psoriasis with calcitriol (15 micrograms per gram/ointment) is more effective than placebo.

Br J Dermatol. 1996 Feb;134(2):238-46. 
Efficacy and safety of topical calcitriol (1,25-dihydroxyvitamin D3) for the treatment of psoriasis.
Perez A, Chen TC, Turner A, Raab R, Bhawan J, Poche P, Holick MF.
PMID: 8746336

14. Treatment of psoriasis with calcitriol (15 micrograms per gram/ointment) cleared 90% of lesions without side effect.

Dermatology. 1994;188(2):135-9. 
Calcitriol (1 alpha,25-dihydroxyvitamin D3) ointment in psoriasis, a safety tolerance and efficacy multicentre study.
Wishart JM.
PMID: 8136540

15. Treatment of psoriasis with calcipotriene (50 micrograms per gram ointment) was an effective alternative to corticosteroids and was without side effect.

Mayo Clin Proc. 1993 Sep;68(9):835-41. 
Comment in:
    Mayo Clin Proc. 1993 Sep;68(9):925-7.
Efficacy of vitamin D3 derivatives in the treatment of psoriasis vulgaris: a preliminary report.
el-Azhary RA, Peters MS, Pittelkow MR, Kao PC, Muller SA.
PMID: 8396699

16. Treatment of psoriasis with calcitriol (3 micrograms per gram ointment) significantly improved lesions.

Br J Dermatol. 1993 Jun;128(6):666-73. 
Topical treatment of psoriatic plaques with 1,25-dihydroxyvitamin D3: a cell biological study.
Gerritsen MJ, Rulo HF, Van Vlijmen-Willems I, Van Erp PE, van de Kerkhof PC.
PMID: 8101716

17. Treatment of psoriasis vulgaris with calcitriol (3 micrograms per gram ointment) once/day was safe and effective for children. After 4 weeks of treatment, psoriasis was completely cleared compared to the application of placebo.

Eur J Pediatr. 1993 May;152(5):389-92. 
Topical application of 1,25-dihydroxyvitamin D3 (calcitriol) is an effective and reliable therapy to cure skin lesions in psoriatic children.
Saggese G, Federico G, Battini R.
PMID: 8319701

18. Treatment of psoriasis with calcipotriol (100 grams ointment/week) was safe and effective treatment with 60 – 70% improvement after 6 – 8 weeks of application.

Tidsskr Nor Laegeforen. 1993 Nov 30;113(29):3580-1.  

[New treatment of psoriasis with the vitamin D analogue calcipotriol]

[Article in Norwegian]

Austad J.

19. Treatment of psoriasis with calcipotriol (50 micrograms per gram up to 100 grams ointment/week) was safe and effective compared to placebo.

J Am Acad Dermatol. 1992 Dec;27(6 Pt 1):1001-8.  

Treatment of psoriasis with calcipotriol and other vitamin D analogues.

Kragballe K.

20. Treatment of psoriasis with calcipotriol (1.2 mg per gram) showed improvement after 1 week and lesions cleared within 6 weeks in many cases compared to placebo.

Acta Derm Venereol. 1989;69(2):147-50.  

Efficacy of topical treatment in psoriasis with MC903, a new vitamin D analogue.

Staberg B, Roed-Petersen J, Menne T.

ZINC

21. Daily treatment with zinc (50 mg/3 times/day) had some effect on psoriasis vulgaris, reducing some inflammation.

Isr J Med Sci. 1990 Jun;26(6):306-9. 
Effect of zinc therapy on neutrophil chemotaxis in psoriasis.
Leibovici V, Statter M, Weinrauch L, Tzfoni E, MatZner Y.
PMID: 2380030

22. Daily treatment with zinc (120 mg/3 times/day) for 6 months decreased swollen and tender joints and reduced the need for anti-inflammatory drugs in patients with psoriatic arthritis.

Recenti Prog Med. 1989 Nov;80(11):577-81. 
[Zinc sulfate in the treatment of psoriatic arthritis]
[Article in Italian]
Frigo A, Tambalo C, Bambara LM, Biasi D, Marrella M, Milanino R, Moretti U, Velo G, De Sandre G.
PMID: 2623320