MIGRAINE

COENZYME Q 10

1. Treatment with coenzyme Q10 (150 mg/day) for 3 months reduced incidence and duration of migraines without side effect in migraine patients.

Cephalalgia. 2002 Mar;22(2):137-41. 
Open label trial of coenzyme Q10 as a migraine preventive.
Rozen TD, Oshinsky ML, Gebeline CA, Bradley KC, Young WB, Shechter AL, Silberstein SD.
PMID: 11972582

MAGNESIUM

2. Compared to placebo, treatment with magnesium (360 mg/day) for 4 months reduced the number of days with headache and reduced premenstrual symptoms in patients with a history of menstrual migraines.

Headache. 1991 May;31(5):298-301. 
Magnesium prophylaxis of menstrual migraine: effects on intracellular magnesium.
Facchinetti F, Sances G, Borella P, Genazzani AR, Nappi G.
PMID: 1860787

RIBOFLAVIN/VITAMIN B2

3. A daily dose of riboflavin (400 mg) was effective in preventing migraines without side effect compared to the triptan family of drugs.

Rev Med Liege. 1999 Feb;54(2):79-86.
[Anti-migraine treatment: present and future]
[Article in French]
Schoenen J.
PMID: 10221059

4. Compared to placebo, a daily dose of riboflavin (400 mg) for 3 months was effective in reducing frequency of, and number of days with migraines with limited side effects.

Neurology. 1998 Feb;50(2):466-70.
Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial.
Schoenen J, Jacquy J, Lenaerts M.
PMID: 9484373

5. A daily dose of riboflavin (400 mg) for at least 3 months was effective in reducing migraines by 68% with no side effects.

Cephalalgia. 1994 Oct;14(5):328-9.
High-dose riboflavin as a prophylactic treatment of migraine: results of an open pilot study.
Schoenen J, Lenaerts M, Bastings E.
PMID: 7828189