LIPID PEROXIDATION
ELLAGIC ACID
Animal Study
(1 micromole = one-thousandth of a gram-molecule)
1. Supplementation with antioxidants curcumin, ellagic acid, bixin and alpha-tocopherol (200 micromoles per kilogram body weight) protected rats from toxicity during whole body radiation.
Indian Journal of Experimental Biology ( INDIAN J. EXP. BIOL. ) (India) 1996, 34/9 (845-847)
Protective effect of curcumin, ellagic acid and bixin on radiation induced toxicity
Thresiamma K.C.; George J.; Kuttan R.
Animal Study
(1 micromole = one-thousandth of a gram-molecule)
2. Ellagic acid (10 micromoles) was the most effective antioxidant at suppressing lipid peroxidation in rat skin flap necrosis compared to curcumin, chlorogenic acid, alpha-tocopherol ferulic acid and gallic acid.
Plastic and Reconstructive Surgery ( PLAST. RECONSTR. SURG. ) (United States) 1994, 94/7 (1027-1037)
Involvement of lipid peroxidation in necrosis of skin flaps and its suppression by ellagic acid
Ashoori F.; Suzuki S.; Jain Hua Zhou; Isshiki N.; Miyachi Y.
VITAMIN B1/THIAMINE
Animal Study
3. Treatment with thiamine (25 mg per kilogram body weight) for 6 weeks during administration of lead to rats reduced lipid peroxidation and decreased the amount of lead accumulating in the liver and kidneys. Rats treated with thiamine had fewer lead-induced lesions in the kidney and liver than untreated rats.
Vet Hum Toxicol. 2000 Aug;42(4):236-7.
Effect of thiamine hydrochloride on lead induced lipid peroxidation in rat liver and kidney.
Senapati SK, Dey S, Dwivedi SK, Patra RC, Swarup D.
VITAMIN B3/NIACIN/NICOTINAMIDE
Animal Study
4. A diet supplemented with taurine and niacin (2.5% each in drinking water) either alone or combined eliminated chemical-induced lipid peroxidation in the lung and pulmonary fibrosis in hamsters.
Adv Exp Med Biol. 1992;315:329-40.
Taurine and niacin offer a novel therapeutic modality in prevention of chemically-induced pulmonary fibrosis in hamsters.
Giri SN, Wang Q.
PMID: 1380762
Animal Study
5. Supplementation with antioxidants, nicotinamide (60 mg per kilogram body weight), methionine (200 mg per kilogram body weight) and vitamin E (150 mg per kilogram body weight) protected rats injected with a carcinogen.
Eksp Klin Farmakol. 1997 Mar-Apr;60(2):68-71.
[The effect of nicotinamide, methionine and alpha-tocopherol on the liver conjugating and mono-oxygenase systems and on lipid peroxidation in hepatosis-hepatitis in rats]
[Article in Russian]
Legon'kova LF, Bushma MI, Zverinskii IV, Abakumov GZ, Zavodnik LV.
PMID: 9206576
VITAMIN E/TOCOTRIENOL
Animal Study
6. Different doses of gamma-tocotrienol (vitamin E) (15 mg, 30 mg and 150 mg per kilogram diet) all decreased blood pressure and lipid peroxides in hypertensive rats.
Clin Exp Hypertens. 1999 Nov;21(8):1297-313.
Effect of gamma-tocotrienol on blood pressure, lipid peroxidation and total antioxidant status in spontaneously hypertensive rats (SHR).
Newaz MA, Nawal NN.
PMID: 10574414
Animal Study
7. Combined treatment with vitamin E (400 – 500 IU per kilogram body weight/day) and the antioxidant drug, stobadine (24.7 mg per kilogram body weight/day) for 10 weeks reduced hyperglycemia, lipid peroxidation and oxidative stress in rats with induced diabetes.
Biochim Biophys Acta. 2002 Oct 9;1588(1):71-8.
In vivo treatment with stobadine prevents lipid peroxidation, protein glycation and calcium overload but does not ameliorate Ca2+ -ATPase activity in heart and liver of streptozotocin-diabetic rats: comparison with vitamin E.
Pekiner B, Ulusu NN, Das-Evcimen N, Sahilli M, Aktan F, Stefek M, Stolc S, Karasu C; Antioxidants in Diabetes-Induced Complications Study Group.
PMID: 12379316
8. Compared to placebo, a single oral dose of vitamin E (1200 IU) taken before hemodialysis reduced lipid peroxidation in patients undergoing hemodialysis and receiving intravenous iron.
J Am Soc Nephrol. 2000 Mar;11(3):539-49.
Vitamin E attenuates oxidative stress induced by intravenous iron in patients on hemodialysis.
Roob JM, Khoschsorur G, Tiran A, Horina JH, Holzer H, Winklhofer-Roob BM.
PMID: 10703678
9. Daily supplementation with vitamin E (100 IU) significantly reduced lipid peroxidation and lipid levels in patients with diabetes.
Lipids. 1996 Mar;31 Suppl:S87-90.
The effect of modest vitamin E supplementation on lipid peroxidation products and other cardiovascular risk factors in diabetic patients.
Jain SK, McVie R, Jaramillo JJ, Palmer M, Smith T, Meachum ZD, Little RL.
PMID: 8729100
Animal Study
10. A diet high in vitamin E (500 IU per kilogram body weight) reduced lipid peroxidation in hyperthyroid rats more effectively than lower doses of vitamin E.
J Nutr Sci Vitaminol (Tokyo). 1989 Oct;35(5):407-18.
Vitamin E protects against thyroxine-induced acceleration of lipid peroxidation in cardiac and skeletal muscles in rats.
Asayama K, Dobashi K, Hayashibe H, Kato K.
PMID: 2632676
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