INFERTILITY
MAGNESIUM
(1 microgram = 0.001 milligrams)
1. When 4 months of magnesium supplementation (600 mg/day) did not normalize red cell magnesium levels in women with unexplained infertility or miscarriage, they were given selenium (200 micrograms/day) for 2 months after which their red cell magnesium (RCM) levels normalized and they all became pregnant within 8 months of normalizing RCM.
Magnes Res. 1994 Mar;7(1):49-57.
Red cell magnesium and glutathione peroxidase in infertile women--effects of oral supplementation with magnesium and selenium.
Howard JM, Davies S, Hunnisett A.
PMID: 8054261
MANGANESE
Animal Study
(1 micromole = one-thousandth of a gram-molecule)
2. Treatment with manganese (0.1 micromole) and magnesium (5 micromole) improved sperm motility in bovine.
Dairy Sci. 1996 Dec;79(12):2163-9.
Modulation of postthaw motility, survival, calcium uptake, and fertility of bovine sperm by magnesium and manganese.
Lapointe S, Ahmad I, Buhr MM, Sirard MA.
PMID: 9029354
SELENIUM
(1 microgram = 0.001 milligrams)
3. Daily doses of vitamin E (400 mg) and selenium (225 micrograms) for 3 months improved sperm motility and quality compared to men receiving vitamin B.
Arch Androl. 2003 Mar-Apr;49(2):83-94.
Sperm oxidative stress and the effect of an oral vitamin E and selenium supplement on semen quality in infertile men.
Keskes-Ammar L, Feki-Chakroun N, Rebai T, Sahnoun Z, Ghozzi H, Hammami S, Zghal K, Fki H, Damak J, Bahloul A.
PMID: 12623744
4. Compared to placebo, daily doses of selenium (3.5 microgram per kilogram body weight/day) for 3 periods of 30 days improved fertility in men. Those receiving selenium for 2 months had higher response than those treated for 30 days.
Urologiia. 1999 Jul-Aug;(4):29-32.
[Selenium correction of male subfertility]
[Article in Russian]
Nikolaev AA, Lutskii DL, Lozhkina LV, Bochanovskii VA, Goncharova LA.
PMID: 11149326
VITAMIN B12/COBALAMIN
(1 microgram = 0.001 milligrams)
5. A dose of vitamin B12 (1000 micrograms) corrected B12 deficiency and resulted in pregnancy.
Int J Fertil. 1991 Jan-Feb;36(1):36-8.
Vitamin B12 deficiency and infertility: report of a case.
Sanfilippo JS, Liu YK.
PMID: 1672674
VITAMIN C/ASCORBIC ACID
6. Daily doses of gradual release vitamin C (500 mg) given to women prior to hormonal stimulation resulted in more pregnancies in the supplemented group versus the non-supplemented group. There were more pregnancies among non smoking than in smoking women.
Cent Eur J Public Health. 2003 Jun;11(2):63-7.
Ascorbic acid and infertility treatment.
Crha I, Hruba D, Ventruba P, Fiala J, Totusek J, Visnova H.
PMID: 12884545
ZINC
7. Daily treatment with zinc sulfate (440 mg) for 60 days to 2 years improved fertility in men, resulting in impregnations especially if they had undergone varicocelectomy.
Urology. 1987 Jun;29(6):638-41.
Zinc sulfate therapy for infertile male with or without varicocelectomy.
Takihara H, Cosentino MJ, Cockett AT.
PMID: 3576896
8. Daily treatment with zinc sulfate (220 mg) for 4 months improved sperm count and motility in infertile men.
Indian J Physiol Pharmacol. 1987 Jan-Mar;31(1):30-4.
Effect of zinc administration on seminal zinc and fertility of oligospermic males.
Tikkiwal M, Ajmera RL, Mathur NK.
PMID: 3666872
9. Doses of zinc (5 – 10 mg/day) combined with androgen, improved sperm motility more than either substance alone.
Urology. 1983 Aug;22(2):160-4.
Effect of low-dose androgen and zinc sulfate on sperm motility and seminal zinc levels in infertile men.
Takihara H, Cosentino MJ, Cockett AT.
PMID: 6879889
10. Men consuming 1.4 mg/day zinc had lower semen volumes than men consuming 10.4 mg/day of zinc.
Am J Clin Nutr. 1992 Jul;56(1):148-57.
Effects of dietary zinc depletion on seminal volume and zinc loss, serum testosterone concentrations, and sperm morphology in young men.
Hunt CD, Johnson PE, Herbel J, Mullen LK.
PMID: 1609752
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