EPILEPSY

VITAMIN B1/THIAMINE

1. Compared to placebo or folate, doses of thiamine (50 mg/day for 6 months) improved neuroppsychological functions (visual/spatial analysis, visual motor speed and non-verbal IQ) in epileptic patients on phenytoin or phenobarbital.

Epilepsy Res. 1993 Oct;16(2):157-63. 
Thiamine and folate treatment of chronic epileptic patients: a controlled study with the Wechsler IQ scale.
Botez MI, Botez T, Ross-Chouinard A, Lalonde R.
PMID: 8269914

VITAMIN B3/NIACIN/NICOTINAMIDE
Animal Study

2. Injection of nicotinamide (100 – 500 mg per kilogram body weight) has antiepileptic properties in cats.

Biull Eksp Biol Med. 1981;91(1):42-5. 
[Further study of the antiepileptic properties of nicotinamide]
[Article in Russian]
Kryzhanovskii GN, Shandra AA, Godlevskii LS, Beliaeva AI.
PMID: 6452183

Animal Study

3. Injection of nicotinamide (50 – 70 mg per kilogram body weight) eliminated epileptic activity in cats.

Biull Eksp Biol Med. 1980 JUL;89(7):37-41. 
[Effect of nicotinamide on epileptic activity in the cerebral cortex]
[Article in Russian]
Kryzhanovskii GN, Shandra AA, Makul'kin RF, Lokasiuk BA, Godlevskii LS.
PMID: 6447523

VITAMIN B6/PYRIDOXINE

4. Injections of vitamin B6 (50 – 100 mg/day for 5 days) followed by oral dose of 200 –300 mg/day reduced seizures in children with drug resistant epileptic encephalopathies.

Cesk Neurol Neurochir. 1989 Jan;52(1):28-31. 
[Administration of high doses of B6  in age-related epileptic encephalopathies]
[Article in Czech]
Zouhar A, Slapal R.
PMID: 2713942

VITAMIN D
(1 microgram = 0.001 milligrams)

5. Daily doses of vitamin D (0.25 micrograms) and calcium (500 mg) increased bone mineral density in children with severe cerebral palsy taking antiepileptic drugs.

Dev Med Child Neurol. 2000 Jun;42(6):403-5. 
Effect of vitamin D and calcium on bone mineral density in children with CP and epilepsy in full-time care.
Jekovec-Vrhovsek M, Kocijancic A, Prezelj J.
PMID: 10875526