The Surprising Psoriasis Treatment

"Medical data is for informational purposes only. You should always consult your family physician or one of our referral physicians prior to treatment - The Arthritis Trust of America

Article provided by:
The Arthritis Trust of America

The Surprising Psoriasis Treatment!
Supplement to The Art of Getting Well

Sources are given in references.
Authors of contributions\quotations are alphabetically arranged; major author, if any, is underlined.

Robert F. Cathcart, M.D., Perry A. Chapdelaine, Jr., M.D., Helmut Christ, M.D., Goeckerman, Wayne Martin, B.S., Gus J. Prosch, Jr., M.D./Responsible editor/writer Anthony di Fabio.

AKA The Arthritis Trust of America,
7111 Sweetgum Road, Suite A, Fairview, TN 37062-9384

I will make no apology for the technical material that is to be read in this chapter. Those with Psoriasis will be happy to use a dictionary to better understand their terrible affliction, and in any case, it is sure that this chapter will be brought to a physician for interpretation and use. That physician will want more than lay language.

The treatment protocol for Psoriasis is simple, and can be read without difficulty.

Brief Background

In July of 1986 The Rheumatoid Disease Foundation brought to its Second National Medical Seminar, Dr. Helmut Christ, M.D. of Bisingen, West Germany, as a speaker.

One of Dr. Christ's subjects was "Psoriasis Under Control at Last".

Gus J. Prosch, M.D., referral physician (AL), was the first to try this new treatment on a patient with success. He obtained Psoriasis medicines from a pharmacy in Germany recommended by Dr. Helmut Christ.

Dr. Prosch's patient had tried everything possible, and he had reached a point of suicidal intent if this next treatment did not help, such was his despair.

Prosch proceeded with a successful trial.

On page 138 of The Art of Getting Well, Helmut Christ, M.D. reported 100% successes¹¹.

Helmut, a physician who wished to be a general practitioner, and did not choose to be a specialist on Psoriasis, as of this writing has 900 patients for Psoriasis, mostly by referral from successful patients and physicians. He did not invent the treatment, but rather received it from another physician who had had Psoriasis himself, and eventually developed the successful treatment protocol which is now being tested through studies by various universities and clinics.

It should be clear from the start that "Fumaric Acid" per se, is useless, but that "Fumaric Acid Monoethylester" and "Fumaric Acid di-Methylester" are the proper medicines.

There are those who sell "Fumaric Acid" alone for this treatment thereby misleading with a substance that will be of no effect whatsoever by itself.

What is Psoriasis?

There are many forms of psoriasis, a skin disease characterized by the formation of scaly red patches on the extensor (following the muscles that perform extension) surfaces of the body.

Annularis Psoriasis in ring-shaped patches

Arthropathica A form associated with chronic arthritis

Buccalis Marked by white, thickened patches in mucuous membrane of cheeks, gums, tongue

Circinata (See Annularis above)

Diffusa Coalescence of large contiguous lesions (Bakers, grocers', bricklayers itch, etc.)

Discoides Occurring in solid patches

Figurata Lesions in curved linear patterns

Follicularis Small, scaly lesions located at openings of sebaceous and sweat glands

Guttata Occurs in small, distinct, irregular patches

Gyrata Having serpentine arrangement

Inveterata With confluent lesions and thickening and hardening skin

Linguae (See Buccalis above)

Nummularis In circular patches that resembles coins

Osteacea In Old, thick, tough patches covered with scales resembling outside of oyster shells

Palmaris et plantaris Syphiloderm of palms or soles

Punctata Lesions consist of minute, red, pinhead-shaped papules, often surmounted with pearly scales

Pustular p. Lesions are covered with pustules

Rupioides Rupia-like crusts (skin eruptions usually from syphilis)

Universalis Lesions over whole body

As one can easily see, these complex Latin terms are simply means for classifying various views of a skin condition and are not at all meaningful for the purpose of treating and controlling the disease except in certain few cases, such as Rupioides, which seems to be related to a germ organism.

If you are one who suffers from Psoriasis, surely you know more about your symptoms than simply how to describe it. You know that it flares up worse then gets better from time to time, that it sometimes can create great embarrassment, pain, guilt - in short, it can indeed control your life.

According to Helmut Christ, M.D.: "It has now been established, that Psoriasis is not a SKIN DISORDER strictly speaking, but instead an inherited metabolic disturbance which is set on by environmental or stressful conditions, like faults in the diet, flu-like conditions, the administration of Penicillin, death of a family member, [medical] operations, etc."

We know that patients with Psoriasis have a higher incidence of Rheumatoid Diseases than others.

What is Psoriasis?

Simply, it is a hyperproliferation (overgrowth) of the epidermis (outer skin covering), and apparently cell division is not normal.

Traditional Treatments

Many treatments are directed at interference with DNA synthesis and interruption of cell division as it is presumed this function is in error in our bodies.

Some patients move to warmer climates to increase sun exposure and humidity, although overexposure to sunlight can also aggravate the condition.

The traditional treatments for psoriasis include topical tars and ultraviolet light, keratolytics, anthralin and glucocorticosteroids. Current systemic therapies using psoralen-photochemotherapy or methotrexate are still largely investigational and may produce adverse effects. Besides blocking the abnormal rapid proliferation of psoriasis, methotrexate affects other normally rapidly growing tissues such as bone marrow, gastrointestinal tissues and hair roots.

Fluorinated steroids may be useful on a short-term basis for treatment of resistant, highly inflamed, or irritated plaques, but are not advisable for treatment of widespread psoriasis. Hydrocortisone creams are commonly used with mixed results for intetriginous (chafed) areas or on the face since they do not atrophy the skin. However, systemic steroids are generally contraindicated, as cessation is usually accompanied by rebound worsening of the disease.

PUVA (Psoralen and long-wave ultraviolet light) have been useful therapies but are still investigational. Side effects include phototoxicity with erythema and blistering, pruritis and nausea. Potential chronic side effects such as actinic damage and aging of the skin, carcinogenesis and cataract formation are of great concern. Moreover, patient compliance is generally poor. An average of 25 treatments given 2 or 3 times weekly are required for 80% clearing of Psoriasis. Patients who work outdoors do not like to wear goggles. Psoralen and long-wave ultraviolet light (PUVA) is only a palliative treatment and requires continued maintenance therapy. At Stanford University, experience with PUVA has shown that over 90% of patients develop recurrent psoriasis in the first year of therapy.

Crude coal tars, often combined with zinc and salicylic acid, has been a valuable adjunctive treatment for psoriasis. Coal tar products are able to suppress DNA synthesis in the epidermis within the first few hours after application. The Goeckerman regimen, combining coal tar with exposure to UV light, has induced remissions for several weeks and is a relatively safe method. Patient compliance is still a problem as these tars are messy and stain clothing. Some patients develop acanthomas (tumor or excessive development of skin). Coal tars also produce folliculitis (inflammation of hair folliculs). The absorbed mutagens may increase the risk of some forms of cancer. Crude coal tar is a mixture of 10,000 non-standarized components, which may create a potential problem of contact allergic sensitization.

The synthetic retinoids are a major advance in the treatment of both localized as well as generalized pusular Psoriasis. The dosage must be carefully monitored, as some patients experience a local recurrence of pustules with the lowered dosage. All of the important factors concerning toxicity and side effects of these drugs need to be considered carefully, especially the teratogenic effects. Some of the side effects are dose-dependent (e.g. dryness of the lips and oral mucosa) and are reversible after discontinuation of therapy. Other side effects include exfoliation (a falling off in scales or layers) of palms and soles, hair loss, conjunctivitis (inflammation of the layer that lines the eyelids), pruritis, paronchia, elevated serum lipids, muscle pain, neuralgia and hyperostosis (bone disorder). Considering the possible long-term effects of retinoid-induced lipid modulation on atherosclerosis and coronary artery disease, it is necessary to closely monitor the levels of serum lipids during therapy, particularly in patients with CHD risk factors. Some of the non-toxic therapies which may be used prophylactically in patients treated with retinoids include niacin (400 mg b.i.d) and L-Carnitine (250 mg b.i.d.).

Methotrexate is often used as a third-line therapy for patients with severe psoriasis (e.g. acute pustular Psoriasis, Psoriatic Arthritis, Psoriatic Erythroderma) unresponsive to other, less toxic therapies. Liver and renal functions must be carefully monitored prior to treatment. Severe liver disease, such as fibrosis and cirrhosis, may be present in patients with Psoriasis, especially in alcoholics. Unfortunately, no liver function tests are reliable indicators of severe liver toxicity. Other risk factors include obesity, diabetes and lowered renal function. One can minimize the risk by titrating the patient to the lowest possible dose to achieve and maintain adequate control, rather than 100% clearing of the Psoriasis. Like many other treatments for Psoriasis, methotrexate is a known teratogen.

Regardless of the treatment used, patient education remains a critical component in the successful management of Psoriasis. Therefore patient education manuals and even support groups will enhance the prognosis of the disease and may even strengthen the base of patient referrals to a dermatologist's practice. Patients should be advised on those factors which make Psoriasis worse. Trauma and irritation of the skin, induced by rubbing, scratching or scrubbing off scales all can produce Psoriasis. Some throat and upper respiratory infections may flare Psoriasis and should be promptly treated by a physician. Some dermatologists are so absorbed in their subspecialty that they overlook the common patient complaints, normally encountered by a general practitioner (e.g. strep infections). Guttate Psoriasis (lesions that are drop shaped) particularly occurs in children and adolescents after strep infections.

Patients should be encouraged to discuss other illnesses besides their chief complaint. Most patients do not understand the fact that sun exposure should be used in moderation. While sunlight in moderation usually helps Psoriasis, sunburn may cause Psoriasis to flare up. A similar situation exists with topical steroids. Patients should be advised not to use these creams on areas in which the Psoriasis is cleared and to follow their dermatologist's directions carefully to preclude a rebound phenomenon. Stress and anxiety should be minimized. Dietary recommendations are outlined in conjunction with our recommended treatment which is also the new European fumaric acid protocol.

Recent evidence points to abonormalities in the arachidonic acid metabolism in patients with Psoriasis. The cyclic AMP/cyclic GMP ratio is decreased in involved epidermis of Psoriasis compared with uninvolved epidermis from Psoriasis patients or epidermis from normal volunteers. The imbalance of the two cyclic nucleotides plays a central role in the pathogenesis of Psoriasis. Usually, tissue levels of free fatty acids are quite low. However, involved epidermis of Psoriasis contains high concentrations of free arachidonic acid. Elevated levels of the prostaglandin series leads to increased platelet aggregation. Fish oils, high in eicosapentaenoic acid and docosahexaenoic acids (EPA & DHA) are currently being used for normalizing aberations in the arachidonic acid cascade. It is interesting to note that the majority of patients with Psoriasis have elevated levels of cholesterol and triglycerides which may result from abnormal platelet behavior. Epidermal cells in Psoriatic lesions have a receptor for serum beta-lipoproteins. The rate of epidermal lipid synthesis may be regulated by serum lipoproteins. Dermatologists are encouraged to observe and control lipid abnormalities with Psoriasis.

One very promising treatment for Psoriasis is based on the use of fumaric acid. Clinical investigations with this unsaturated dibasic acid have been conducted in University Medical Centers in Switzerland, West Germany, Japan and the Netherlands and the results are promising. Fumaric acid is the trans isomer of malic acid and an intermediate in the Krebs citric acid cycle. Fumaric acid has been used both topically and orally and a titration protocol has been suggested.

Rationale for Use of Fumaric Acid

Psoriasis is regarded as a disease resulting from a metabolic error, possibly a defect of fumaric acid metabolism. Fumaric acid is the trans isomer of malic acid. It is an important compound biochemically since it enters into the citric acid cycle. Fumarate is a by-product at certain stages in the arginine-urea cycle and in purine biosynthesis. Since the citric acid cycle is the center for energy production with the cell, fumaric acid must be present in every cell of the body as it is a by-product of the cycle. Although fumaric acid is not a foreign substance, it is metabolically very active.

In healthy individuals, fumaric acid is formed in the skin when it is exposed to sunlight (from the ultra-violet part of the spectrum). Apparently, patients suffering from Psoriasis have a biochemical defect in which they cannot produce enough fumaric acid and need prolonged exposure to the sun to produce it. This is one reason why patients frequently notice an improvement of their skin condition in the summer months and also explains, in part, the efficacy of PUVA treatment.

This protocol for the treatment of Psoriasis with fumaric acid capsules is based on several clinical studies conducted at the Beau Reveil Clinic in Leysin, Switzerland and the West End Hospital in den Haage, Netherlands. Studies were reported in the following journals: Ned. Tijdschr. Geneeskd., Gann, Med. Msch., Biochem. Pharm., Arch. Derm. Res. and Arch. Derm. Forsch.

Further references follow at the end of this article, but hereafter I shall follow the protocol as presented by Helmut Christ, M.D. and used by Gus Prosch, Jr., M.D. and other referral physicians of The Rheumatoid Disease Foundation.

Psoriasis Treatment Protocol
(From Helmut Christ, M.D.)

We believe that patients suffering from Psoriasis have a lack of fumaric acid. In healthy individuals, fumaric acid is formed in the skin when it is exposed to sunlight (from ultra-violet part of the spectrum). Apparently the patient suffering from Psoriasis cannot make fumaric acid that easily, so that he suffers a lack of the acid and needs a longer exposure to the sun to produce it. This is why these patients frequently notice an improvement of their skin condition in the summer months. The aim of our treatment is therefore not only the application of ointments and creams on the skin or its exposure to ultra-violet light, but the careful oral administration of the lacking fumaric acid. This is the basis of our treatment. At no time is the patient treated with cortisone, either by mouth or on his skin. (The patients frequently come from Dermatologists or University clinics, having been treated for years with Cortisone orally or as part of the ointment.)

What is fumaric acid?

Chemically it is an unsaturated dicarbonic acid and is part of the citric acid cycle.

CH - COOH
| |
CH - COOH

As the citric acid cycle is the center for energy production within the cell, fumaric acid must be present in every cell of the body, being a by-product of the cycle. It is therefore not something that is foreign to the body. A lack of fumaric acid leads to the accumulation of half-products. These products, we believe, are responsible for the skin lesions in patients with Psoriasis. In administering the lacking fumaric acid slowly to the body, the Psoriasis can come to a halt. The administration of the acid should be slow, as it is a metabolically very active substance. However the administration of too little fumaric acid will result in a therapeutic failure, whereas too much can lead to heat waves and a drop in blood sugar. This is a very rare occurrence.

The patient with Psoriasis may eat and drink everything that does not produce itching of the skin.

The rule is: If it itches today, then there was something in the food yesterday that his/her skin cannot tolerate. In this way every patient must eventually find out for themself what foods and spices their skin can tolerate and what foods should be avoided. I find it amazing that no Dermatologist or Skin clinic advises the patients in this way, but if one takes a careful history, the doctor will discover that many patients avoid certain food stuffs. A guideline for allowed foods is included.

Other factors which can trigger off a relapse in the skin condition are acute illnesses accompanied by high temperatures, and conditions accompanied by accumulation of pus, like purulent tonsillitis, skin abscesses, root-abcesses of teeth, mycotic infections, cellulites, pyorderma, etc. These should be treated immediately and vigorously.

It is advisable that the patient exercise frequently (jogging) and really sweat.

TREATMENT PROTOCOL

Fumaric Acid Tablets (Strength I and II):

At the end of every evening the patient should take his tablet with a lot of fluid either tea, mineral water or preferably milk as this will reduce stomach acidity. If the patient gets an uneasy epigastric feeling after about an hour, he should take the capsule with a little sugar, as the blood sugar may drop a little at this time. (Of course diabetic patients will experience an improvement of their diabetic state - watch the fasting blood sugar a little more carefully.) The patient should not take the fumaric acid with coffee as this will increase gastric acidity, and cause more epigastric discomfort. If he wants to he can also take the tablet dissolved. After about 15 to 30 minutes he will notice a warm feeling and a tingling of the skin, the shoulder, and neck region up to the ear lobes. This reaction lasts approximately half an hour. This indicates that the metabolic process has started. Very rarely the reaction can also come on several hours after taking the tablet and occasionally it may be felt over the whole body. School children should be watched a little more carefully and should carry sweets with them, as they may experience a slight fainting after about 2 to 3 hours from a drop in blood sugar.

The fumaric acid tablets are the basis of the treatment, and they actually affect pH in the digestive tract, resulting in better digestion of foods. It is important for every patient to find out the right dose of fumaric acid that he needs to keep his skin clear. The dosage may be very variable. If a certain dose does not lead to an improvement of the skin, he should increase the number of tablets every 2 to 3 weeks by ONE tablet (capsule) only. As long as he experiences a warm or tingling feeling in the neck and shoulders or as long as the lesions are slowly subsiding, he can stick to the same dose.

Fumaric Acid Ointment

The pharmacist will prepare this ointment for you. It should be used if the lesions are localized or confined only to the elbows and knees. Very small amounts should be rubbed into the skin lesions daily. An erythema (morbid skin redness) after the application is a good sign. DO NOT apply bandages together with the ointment - else the erythema will be very severe and the skin will burn. One may alternate the fumaric ointment with a salicylic acid ointment if the skin reaction is severe. Rub the ointment only on small areas and only on lesions which appear most active. If the skin tends to become very dry, apply a fattening ointment.

Fumaric Acid Bath

Please notice that this solution should not be added to the bath, but also applied to the skin. The bottle should be mixed well before use. If the patient has very diffuse lesions over the whole body, he should use this solution and rub it very sparingly into the skin and wait for approximately 10 minutes (while the bath is being filled). The water should not be too hot and the bath should not last longer than about 15 minutes. When the lesions begin to subside, the ointment should be used for the remaining areas as described above.

Fumaric Acid Lotion

In West Germany Dr. Christ is using a lotion that is rubbed into the scalp immediately after washing the hair, so that it becomes diluted a little - else a slight burning sensation may occur. According to Christ, it is (translated from the German the best possible at this writing):

Fumaric Scalp Lotion Prescription (FS-Lotio)

(RP!) Fumaric Acid 4.0

Monoethyl fumarate 4.0

Infiltrina 10.0 (Something to cause infiltration of scalp, like DMSO-dimethylsulfoxide, perhaps)

Solutio Cordes ad 100.0

MDS. (Place Where It is To Be Used): Scalp Lotion (Kopfhaut-Lotio)

General Measures

The natural course of the illness is one of remissions and relapses. If possible the patient should avoid stressful situations.

Dr. Christ suggests that any patient who is seriously interested in getting rid of Psoriasis, to drink absolutely no alcohol, at least until the skin is clear. If the patient's skin does not recover within a few weeks, he suggests to give the patient liver tablets, especially those metabolic products which are found in the fumaric acid cycle (L-Arginine, L-Citrulline, L-Aspartate and L-Ornithine). He would give these in the form of an injection intravenously every day for 2 to 3 weeks. Very frequently the patient will then experience a dramatic improvement of the skin.

It is most important to avoid wines of all kind, as these can produce a relapse. They should also not be used in cooking, gravies, etc.

Nuts of all kinds should be avoided, except almonds. Dissolved aromatic substances in the nuts are the cause of an exacerbation. Peanuts and products made of them (e.g. butter) must be strictly avoided, also mustard, pepper, curry, etc.

Most important for the treating physician to remember:

1. Always start the treatment with fumaric acid tablets of low concentration. Increase the number of tablets slowly, every 2 to 3 weeks. The maximum dose is 2 to 3 tablets of strength III. As long as the patient experiences the warm tingling feeling over the neck and shoulders, or as long as he notices that the skin lesions are slowly subsiding, he need not increase the dose.

2. Always remind the patient, that around the 10th to 14th day he/she might experience a slight worsening of itching, or may develop slight edema. This is only transient, if it does occur, and lasts only a few days. If really necessary, you might give a diuretic or antihistaminic preparation - usually it is not a problem.

3. The patient should never get penicillin vk. If an infection does have to be treated with an antibiotic, give any other drug except Pencillin VK and watch the patient a little more carefully regarding a relapse. Several other medications will also prevent skin improvement, namely the following ACE - inhibitors: (Angiotensin Converting Enzyme), Calcium-antagonists and beta-blockers, like propranolol.

4. Ointments should be applied very thin and should never be covered up (no bandages, no band-aids, etc.).

5. It is most important that the patient stick to the diet, at least for 2 to 3 months. Only when the skin has recovered completely, should he/she start adding spices to foods and try different foods to find out what his/her skin will tolerate.

6. I would not advise the patient to use ultra-violet light additionally. I doubt whether improvement of the skin is accelerated in this way - and besides, there are several reports from the United States of an increased rate of skin cancer.

7. When the skin is clear (no scars are left behind on healing) the patient may slowly try to reduce the number of fumaric acid tablets. If the skin does start to itch again, he must continue with the dose that kept the lesions away.

8. Reassure the patient that he/she is taking a harmless medication which is not foreign to his body and has no serious side-effects on the liver, kidney, etc. I reassure the patient by showing him the laboratory data regarding hepatic and renal function.

9. If the skin does not clear up, the patient is either not taking his medication correctly (that is too little medication), or he/she is not sticking to the diet, or the diagnosis is incorrect. Mycotic infections may mimic Psoriasis and antimycotic treatment should be tried if the fumaric acid treatment does not bring the expected improvement.

(Helmut Christ,M.D. says: "I am still waiting for the first patient who does not show an improvement - sometimes it just takes a couple of weeks longer!")

10. Additional recommendations (besides the diet) are that patients should also take Omega-3-fattyacids and Omega-6-fattyacids. This was a chance finding and was published in The Lancet Nr. 8582, p. 378-380.

Dietary Recommendations for Psoriasis

Foods to be Avoided

Meat: Pork

Spices: All types of aromatic seasoning, pepper, ginger, clove, nutmeg, caraway, anise (licorice), cinnamon, mustard, red pepper, seasoned foods, e.g. sausages, mixed seasoning, (seasoning salt), pre-spiced dishes (e.g. salami, luncheon meats, bouillon cubes), mayonnaise, orange syrup, candied lemon peel, lemon flavoring or extract.

Nuts: Filberts, Hazelnuts, peanuts, all products made of peanuts, e.g. butter, cakes, etc., peanut oil, walnuts, chocolate with nuts.

Alcohols: Wines of all sorts, wine-vinegar, cognac, champagne, sherry, vermouth, port, malaga, liquer, all other alcohols or foods containing alcohols.

Foods Allowed

Meat: Fish, beef, venison, poultry.

Fruit: All types, tomatoes, fruit-vinegar.

Vegetables: All types, rice, potatoes, pasta, cabbages, saffron, legumes (without forbidden spices).

Spices: garlic, onion, herbs, parsley, chives, peppercorn, etc.

Oils: olives, olive oil, saffron.

Nuts: coconuts, almonds, all products made of almonds. Pastries: Various kinds.

Highly Recommended

Hand-pressed fresh fruit juices, lots of beetroot-juice, carrot-juice, milk products (yoghurt, curd), sauerkraut, pickles without pepper, half-sour pickles.

This diet recommendation is that of both Helmut Christ, M.D. and Clinique Beau Reveil, CH 1854, Leysin Switzerland.

Remember Dr. Christ's statement:

If the skin does not clear up, the patient is either not taking his/her medication correctly (that is, too little medication), or he/she is not sticking to the diet, or the diagnosis [of Psoriasis] is incorrect.

Psoriasis-Therapy of Dr. med. Schafer and Dr. med. Christ (Translated the best possible at this writing)

Salve:

1. Fumaric Acid Monoethylester 1.5

2. Skin Cream (DDD*) 15.0

3. DMSO (Dimethylsulfoxide) 8.0

4. Milk Acid Ethylester 1.0

5. Glyoxylic Diureide 1.0

6. Eucerin anhydric to 50.0

* Skin Cream (DDD) Composition: Salicylic Acid, Camphor, Chlorobutanol, Phenol, Methylsalicylate, Thymol. This is a mixture of substances, in different strengths, available through pharmacies in Germany and England, and with these properties (according to German package insert): "DDD penetrates deep into the skin tissue and, because of its antiseptic and antibacterial force, it fights effectfully inflammation and pus instigators. DDD activates the metabolism process in the skin, promotes the blood circulation and provides better nutrition of the cells, better extraction of disease agitators and promotes the new formation of healthy, hardy tissue. Itching, tension in the skin, and pain sensations disappear most immediately after the application." (Produced in license of DDD Ltd., England by DDD Lab, 1000 Berlin, 30 Delta Clinic, 6078 New Isenburg.)

Psoriasis-Bath:

1. Fumaric acid 100 g

2. Balneum Herb Bath 500 ml

Taken From the German From Helmut Christ

1. Fumaric Powder Capsule I

Fumaric Acid Monoethylester - Metal Salts:

F. - Fe Salt              0.100g
F. - Ca Salt              0.400g
F. - Mg Salt              0.400g
F. - Li Salt              0.200g
F. - K Salt             0.200g
F. - Zn Salt              0.400g
F. - Cu Salt              0.020g
Fumaric Acid              0.600g
Fumaric Acid dimethyl Ester     0.600g

These constituents (to go into) 20 capsules. Generally, should be taken after meals, the amount determined by the doctor.

NOTE: For the prescription it is sufficient to use the name "Fumaric Powder Capsule I." For chronic therapy an amount of 120 capsules is recommended for the prescription.

2. Fumaric Powder Capsule II

Fumaric Acid Monoetheylester - Metal Salts:

F. - Ca Salt              1.0g
F. - Fe Salt             0.12g
F. - Cu Salt             0.02g
F. - Mg Salt             0.8g
Fumaric Acid dimethyl Ester     2.4g
Magnesium Carbonate         0.8g
Zincum Oxide             0.2g

These constituents (to go into) 20 capsules. Generally, should be taken after meals, the amount determined by the doctor.

NOTE: For the prescription it is sufficient to use the name "Fumaric Powder Capsule II." For chronic therapy an amount of 120 capsules is recommended for the prescription.

3. Fumaric Acid Bath

Fumaric Acid 100.0
Balneum Herbal Oilbath 500.0

Usage: As soon as you have wet your body in the shower, you use this bath liquid, and after that use the powder on the skin lesions. After waiting 5 minutes for it to take effect, rinse off the whole body with water.

4. Fumaric Salve I

Fumaric Acid Monoethylester    3.0
Glyoxylic Diureide         3.0
Lactic Acid Ethyl Ester         3.0
DMSO             10.0
DDD - Soothing Skin Cream     40.0
Eucerin anlydricum to        100.0

Usage: According to instructions of doctor. Fumaric Salve I is for the patient with strong itching.

NOTE: For the prescription it is sufficient to use the name "Fumaric Salve I."

Helmut Christ, M.D. states that he has had no experience with items 5, 6, and 7 that follow, but they were so interesting, and they might be useful and so I include them .

5. Fumaric Salve II

Fumaric Acid Monoethylester    3.0
Glyoxylic Diureide         3.0
Decoderm Basis Cream         40.0
Eucerin With Water to         100.0

Usage: According to instructions of doctor. Fumaric Salve II is only for skin care.

NOTE: For the prescription it is sufficient to use the name "Fumaric Salve II."

6. (Scalp) Head Alcohol

Fumaric Acid 2.5
Fumaric Acid Monoethylester 2.5
DMSO 5.0
Spiritus Cordes to 100.0

Usage: According to instructions of doctor.

7. Fumaric Fingernail Polish

Griseofulvin              0.01
Fumaric Acid Monoethylester     0.5
Benzoic Acid Ethyl Ester     0.3
Mallebrin             0.1
Talcum             0.05
Cellulose Nitrate Lacquer to 10.0

Usage: According to instructions of doctor.

The following is an interesting letter from Helmut Christ, M.D. to Robert F. Cathcart, M.D., a copy forwarded to me at Christ's request, March 1, 1989:

"Thank you very much for your letter dated Dec. 1, 1988. Please excuse the long delay for answering, but as you guessed, I am being flooded with letters from physicians and patients in the U.S. wanting to know more about the treatment [Psoriasis, Ed:] and where they can get the medication.

"It appears that physicians in this country are slowly wakening up and becoming more and more alert to this very successful type of treatment and I just cannot cope any more. I am seriously considering having another physician to assist me.

"Other medications that interfere with the fumaric acid treatment - this is an interesting subject. I don't know why Beta-blockers, Calcium-antagonists and Angiotensin-converting-enzyme inhibitors prevent the psoriatic lesions from healing off. It could be a local effect at the site of the scales on the skin. However I believe that these drugs interfere in metabolic pathways, either in the citric acid cycle or the fumaric acid cycle, which is closely connected to the former. You are reading my thoughts by suggesting that fumaric acid may act as a type of antibiotic in the bowel killing . . . organism[s]. How else can you explain that Metronidazole gives some improvement in patients with psoriasis. Maybe one should try both substances in patients -- 10% - who just don't want to get better. One should investigate this problem with bacteriological sensitivity tests.

"Another interesting aspect is that if you give these patients the metabolic products of the fumaric acid cycle, e.g, L-Citrulline, L-Argnine, L-Ornithine, L-Aspartate (The L-amino acids), intravenously you can watch the patient getting better week to week.

"As far as literature [scientific studies] goes, I have a large collection, but it is all in German! I would suggest that you order the capsules, ointment, bath and lotion for the scalp on a regular basis - BUT IN SMALL AMOUNTS - from our pharmacist[s] in Germany. I have heard from several patients in the U.S. that they are getting the fumaric acid from . . . and some trace minerals and the whole thing doesn't help the patient at all. The secret is that it is important that the 'Ester' form of the fumaric acid has to be used and not fumaric acid as such, alone."

On March 10, 1985, Christ transmitted to this author two addresses in West Germany that can supply the proper medicines. They are: Herr Horst Widmann, "Stadt - Apotheke", Friedrichstrabe 27, 7460 Balingen; and Herr Winfried Ertelt, "Hohenzollern - Apotheke", Steinhofenerstrabe 14, 7457 Bisingen. Also in the United States, Cardiovascular Research Ltd. 1061-B Shary Circle, Concord, CA 94518 sells under the name of Psorex; phone 1-800-888-4585; (510)-827-2636.

[I would like to apologize in advance for possible incomplete or mistaken translations of the materials forwarded to us by Helmut Christ, M.D.. Perry A. (Tony) Chapdelaine, M.D. is responsible for translations that are presented for which thanks are due.

References

1. Chopra, D.P. & Flaxman, B.A. Comparative proliferative kinetics of cells from normal human epidermis and benign epidermal hyperplasia (psoriasis) in vitro. Cell and Tissue Kinetics. 7.69, 1974.

2. Weinstein, G.D. & Frost, P. Abnormal cell profliferation in psoriasis. J. Invest. Derm. 50:254, 1968.

3. Schweckendiek, W. Helilung von Psoriasis vlugaris. Med. Msch. 13:103-104, 1959.

4. Kuroda, Z. and Akao, M. Antitumor and anti-intoxication activities of fumaric acid in cultured cells. Gann, 72:777-782, 1981.

5. Hagedorn, K. et al. Fumarsauremonoathylester: Wirkung auf DNA-Synthese und erste tierexperimentelle Befunde. Arch. Derm. Res. 254:67-73, 1975.

6. Bruynzeel, D. Kan fumaarzuur worden toegepast bij psoriasis? Ned. Tijdschr. Geneeskd. 128(35):1677, 1984.

7. Petres, J. et al. Der Einfluss von Fumarasuremono-athylester auf die Nucleinsaure-und Proteinsynthese PHA-stimulierter menschlicher Lymphocyten. Arch. Derm. Forsch. 251:295-300, 1975.

8. Baron, D. fumaarzuur worden toegpast bij psoriasis (Vraag en Antwoord). Ned. tijdschr. Geneeskd. 128(24):1152-1153, 1984.

9. van Dijk, E. Fumaarzuur voor de behandeling van patienten met psoriasis. Ned. Tijdschr. Geneeskd. 129(11):485-486, 1985.

10. Kuroda, K. and Akao, K. Reduction by fumaric acid of side effects of Mitomycin C. Biochem. Pharm. 29:2839-2844, 1980.

11. Anthony di Fabio, The Art of Getting Well, the Rheumatoid Disease Foundation, 5106 Old Harding Road, Franklin, TN 37064, 1988.

I also refer the reader to Townsend Letters for Doctors article "Immunosuppression of Polyunsaturated Fatty Acids in Autoimmune Diseases, Cancer and Heart Attacks" written by Wayne Martin, published July 1988, p. 271. [The Townsend Letters is an informal newsletter for doctors communicating to doctors, and is available by subscription (for those interested) by writing to Townsend Letters for Doctors, 911 Tyler Street, Port Townsend, WA 98368.]

A tape of Dr. Helmut Christ's talk "Psoriasis Under Control at Last - A New Alternative Treatment" is available through Insta-tape, Inc., P.O. Box 1729, Monrovia, CA 91016-5729 [1 (800) 322 TAPE] or California residents call (818) 303-2534.

Psoriasis and Liver Sclerosis

The Case of Christopher Salvadore del Rio

Dr. Catherine Russell,21 Guadalajara, Mexico, describes a "most pathetic psoriasis patient that, through 20 years of cortisone treatment, had reached the point of sclerosis." Traditional physicians had told him "We can't do anything more for you. Just go home and die."

Christopher's niece described her uncle's condition to Dr. Russell, as Dr. Russell loved to get so-called hopeless cases.

Dr. Russell obtained fumaric acid esther as recommended by Helmut Christ, M.D. of Bisingen, Germany, starting Christopher on that substance as well as saturating him with vitamin C to negate the effects of the cortisone. She also addressed Christopher's obvious liver problem. As she didn't know about the benefits of milk thistle extract for the liver at the time, Dr. Russell addressed Christopher's sclerosis problem with homeopathic medicine, B complex.

Christopher's psoriasis and liver sclerosis were totally cleared up, based on laboratory tests made at the same location that had been administering his cortisone shots. The liver cleared up in about 2 years.

Pyrithione Zinc

Used effectively for more than 10 years in Europe is Pyrithione Zinc, chemically a 2% spray of C10H8N2O2Zn, or bis-[1-hydroxy-2(1H)-pyridinethionato-O,S]zinc. The spray substance consists of 2 mgs per milliliter (2mg/ml) of pyrithione zinc. Sprayed twice a day over the skin provides what appears to be permanent cure, even for the worst cases, according to reports by several medical doctors, doctors of osteopathy, and chiropractors. At most 1 to 2 cans are required to bring relief.

Successful clinical trials have been carried out in Spain and Argentina, according to a report by medical journalist, Morton Walker, D.P.M. as published in Townsend Letter for Doctors and Patients, January 1997, page 58.

This substance, Skin-Cap Spray, can be ordered via Progressive Laboratories, Inc., 1701 W. Walnut Hill Ln., Irving, TX 75038; (800) 527-9512.

Staphylococcus Antibody/Complement

This Christmas (1998) I spent watching the application of specifically prepared antigen/complement materials from bovine colostrum, the cow's first milk on calving (See our Universal Oral Vaccine).

What I personally observed was a kind of Christmas miracle. Nowhere had I ever read or heard of Psoriasis being related to staphylococcus. Here's what I observed:

A patient had gross, raised blotches of skin Psoriasis that would not heal no matter what treatments were tried.

A liquid preparation of staphylococcus antibody/complement was taken orally, 1 teaspoon each hour, and a cotton ball was also used to wipe the mixture on the Psoriasis blotches. The wiping on of the liquid was done every time itching occurred, and also occasionally throughout the next days. Also the oral treatment of the liquid was continued each hour.

Within minutes (literally) of the first wiping the blotches began to disappear. Within a day, all blotches were reduced in size. Within two days, only the longest standing, and grossest blotches remained.

Finally, all marks were gone! What a great Christmas present!