CHRONIC VENOUS INSUFFICIENCY

PYCNOGENOL

1. Compared to placebo, pycnogenol supplementation (100 mg 2 – 3 times/day for 2 months) more effectively improved leg heaviness, edema and reduced venous pressure in patients with chronic venous insufficiency.

Phytomedicine. 2000 Oct;7(5):383-8. 
PYCNOGENOL in chronic venous insufficiency.
Petrassi C, Mastromarino A, Spartera C.

2. Compared to placebo, pycnogenol supplementation (100 mg/3 times/day for 2 months) reduced edema, heaviness and pain in legs. Some patients (60%) had complete disappearance of edema and leg heaviness (33%). There were no side effects.

Fitoterapia. 2000 Jun;71(3):236-44. 
Pycnogenol in chronic venous insufficiency.
Arcangeli P.