CHEMOTHERAPY/RADIATION
NARINGIN
Animal Study
1. Naringin (2 mg per kilogram body weight) was administered to mice before they were
exposed to gamma radiation. Naringin protected the bone marrow cells from DNA
damage and reduction in cell proliferation.
Mutat Res. 2002 Aug 26;519(1-2):37-48.
The grapefruit flavanone naringin protects against the radiation-induced genomic
instability in the mice bone marrow: a micronucleus study.
Jagetia GC, Reddy TK.
Department of Radiobiology, Kasturba Medical College, Manipal 576119, India.
gc.jagetia@kmc.manipal.edu
Animal Study
2. A diet including naringin (10 mg per milliliter) for 7 days decreased
benzo(a)pyrene hydroxylase (AHH) activity in mice. (AHH is a carcinogen).
Thus, naringin may be an effective chemoprotectant.
Life Sci. 1999;65(24):2591-602.
In vitro and in vivo effects of naringin on cytochrome P450-dependent
monooxygenase in mouse liver.
Ueng YF, Chang YL, Oda Y, Park SS, Liao JF, Lin MF, Chen CF.
National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC.
ueng@cma23.nricm.edu.tw
PYCNOGENOL
Animal Study
3. Doses of pycnogenol (150 – 200 mg per kilogram body weight) provided significant protection in mice from anticancer drug toxicity.
Phytomedicine. 2002 Jul;9(5):414-8.
Effect of PYCNOGENOL on the toxicity of heart, bone marrow and immune organs as induced by antitumor drugs.
Feng WH, Wei HL, Liu GT.
SELENIUM
4. Chemotherapy patients were given selenium (4 mg) 4 days before and after chemotherapy, which protected from nephrotoxicity and bone marrow suppression.
Biol Trace Elem Res. 1997 Mar;56(3):331-41.
The protective role of selenium on the toxicity of cisplatin-contained chemotherapy regimen in cancer patients.
Hu YJ, Chen Y, Zhang YQ, Zhou MZ, Song XM, Zhang BZ, Luo L, Xu PM, Zhao YN, Zhao YB, Cheng G.
PMID: 9197929
Animal Study
5. A dose of sodium selenite (0.5 mg per kilogram body weight) in pregnant mice two hours before irradiation decreased the number of deformed fetuses.
Acta Radiol Oncol. 1985 May-Jun;24(3):267-71.
Protective effect of selenium against ionizing radiation-induced malformations in mice.
Cekan E, Tribukait B, Vokal-Borek H.
PMID: 2994379
SUPEROXIDE DISMUTASE
6. An injected dose of superoxide dismutase (4000 IU) given prior to radiotherapy, significantly diminished reaction to radiotherapy without side effects.
Hunan Yi Ke Da Xue Xue Bao. 1998;23(3):308-10.
The second phase clinical observation of anti-radiation effect by superoxide dismutase]
Tu Q, Tang J, Shen L, Lei Y, Yu S, Zhou J, He J, Chen C, Zhang F, Zhang F, Dong F, Peng H, Tan H.
PMID: 10681768
Animal Study
7. Doses of manganese superoxide dismutase (50 mg per kilogram body weight) or copper/zinc superoxide dismutase (100 mg per kilogram body weight) each protected rats from radiation injury in the head and neck.
Arch Oral Biol. 2000 Sep;45(9):741-7.
Partial protection of rat parotid glands from irradiation-induced hyposalivation by manganese superoxide dismutase.
Nagler RM, Reznick AZ, Slavin S, Nagler A.
PMID: 10869487
VITAMIN A
8. A twice-daily dose of vitamin A (8000 IU) for 7 weeks completely healed a post radiation anal ulcer in an HIV patient.
Dis Colon Rectum. 2003 May;46(5):679-82.
Oral vitamin a therapy for a patient with a severely symptomatic postradiation anal ulceration: report of a case.
Levitsky J, Hong JJ, Jani AB, Ehrenpreis ED.
VITAMIN B3/NIACIN
(1 gram = 1000 milligrams)
9. A dose of nicotinamide (6 grams) 90 minutes prior to radiotherapy combined with carbogen breathing was well tolerated with limited side effects and no skin reaction.
Br J Radiol. 1995 Feb;68(806):215-8.
Short communication: the addition of carbogen and nicotinamide to a palliative fractionation schedule for locally advanced breast cancer.
Pigott K, Dische S, Saunders MI.
PMID: 7537598
VITAMIN B3/NIACIN
10. Administration of nicotinamide (80 mg per kilogram body weight) before patients received the second radiation treatment for metastatic tumors, increased oxygen that reached the tumor tissue thus potentially increasing the effectiveness of radiation treatment.
Radiother Oncol. 1997 Nov;45(2):175-82.
Impact of nicotinamide on human tumour hypoxic fraction measured using the comet assay.
McLaren DB, Pickles T, Thomson T, Olive PL.
PMID: 9424009
Cell Study
11. A dose of 1.0 mg per gram nicotinamide, combined with carbogen increased the effect of radiotherapy on cancer cells with low toxicity.
Radiother Oncol. 1993 Aug;28(2):162-7.
Radiosensitization of SCCVII tumours and normal tissues by nicotinamide and carbogen: analysis by micronucleus assay.
Ono K, Masunaga S, Akuta K, Akaboshi M, Abe M.
PMID: 8248558
VITAMIN C
12. Vitamin E (400 IU/3 times day) and vitamin C (500 mg 3 time/day) for 1 year improved symptoms of radiation procitis.
Am J Gastroenterol. 2001 Apr;96(4):1080-4.
Successful and sustained treatment of chronic radiation proctitis with antioxidant vitamins
E and C.
VITAMIN D
13. A daily dose of alfacalcidol (0.4 micrograms per kilogram body weight) for 6 months, works synergistically with chemotherapy, radiation or surgery, to produce significant regression in tumors.
J Neurooncol. 2001 Jan;51(1):57-66.
Redifferentiation therapy in brain tumors: long-lasting complete regression of glioblastomas and an anaplastic astrocytoma under long term 1-alpha-hydroxycholecalciferol.
Trouillas P, Honnorat J, Bret P, Jouvet A, Gerard JP.
PMID: 11349882
VITAMIN E/TOCOTRIENOL
Animal Study
14. A subcutaneous dose of vitamin E (400 IU per kilogram body weight) protects against the toxic effect of cobalt-60 radiation in mice.
Mil Med. 2002 Feb;167(2 Suppl):57-9.
Nutritional approaches to radioprotection: vitamin E.
Kumar KS, Srinivasan V, Toles R, Jobe L, Seed TM.
PMID: 11873518
Animal Study
15. Daily doses of vitamin A (3.5 IU), vitamin E (0.107 IU) and vitamin C (4 mg) reduced radio-immunotherapy myelosuppression and weight loss while increasing white blood cell counts in mice.
Int J Cancer. 2000 Apr 15;86(2):276-80.
Anti-oxidant vitamins reduce normal tissue toxicity induced by radio-immunotherapy.
Blumenthal RD, Lew W, Reising A, Soyne D, Osorio L, Ying Z, Goldenberg DM.
PMID: 10738257
Animal Study
16. Injected doses of vitamin E (100 IU per kilogram body weight) given to mice 1 hour before or 15 minutes after exposure to radiation significantly increased survival rate of the injected mice.
Int J Radiat Oncol Biol Phys. 1992;23(4):841-5.
Radioprotection by vitamin E: injectable vitamin E administered alone or with WR-3689 enhances survival of irradiated mice.
Srinivasan V, Weiss JF.
PMID: 1319980
Animal Study
17. Doses of vitamin E (30, 60 or 120 IU) given to rats, accelerated the healing of wounds exposed to radiation.
Int J Vitam Nutr Res. 1987;57(2):133-7.
Increasing the breaking strength of wounds exposed to preoperative irradiation using vitamin E supplementation.
Taren DL, Chvapil M, Weber CW.
PMID: 3654105
Cell Study
18. Cells taken from humans who had been supplemented with vitamin E (500 IU/day) for 16 days were resistant to radiation-induced hemolysis (breakdown of red blood cells).
Radiat Res. 1983 Aug;95(2):303-16.
Resistance of human erythrocytes containing elevated levels of vitamin E to radiation-induced hemolysis.
Brown MA.
PMID: 6611850 |
