BURN WOUNDS/WOUND HEALING
COPPER
1: For children with severe burn injuries, this study recommends copper being added to parenteral nutrition (IV) in amounts greater than the 20 micrograms per kilogram body weight which is the normal pediatric dose.
Nutrition. 1993 Jul-Aug;9(4):329-32.
Burn severity, copper dose, and plasma ceruloplasmin in burned children during total parenteral nutrition.
Cunningham JJ, Leffell M, Harmatz P.
PMID: 8400588
N-acetyl L-cysteine (NAC)
Animal Study
2. The antioxidants N-acetylcysteine, (1 mg per kilogram body weight/day) and vitamin-C
(0.5 mg per kilogram body weight/day) with allopurinol, desferrioxamine and PEG-catalase were
given to rats for 7 days following a burn injury which improved the contact
hypersensitivity response and immunosuppression
Burns. 1999 Mar;25(2):113-8.
The effect of antioxidant therapy on cell-mediated immunity following burn injury in
an animal model.
Cetinkale O, Senel O, Bulan R.
SUPEROXIDE DISMUTASE
Animal Study
3. Administration of superoxide dismutase (0.47 mg per kilogram body weight/day) prevented burn disease and organ injury in rats with deep burns on 20% of body surface.
Bull Exp Biol Med. 2002 Dec;134(6):578-82.
Erysod, erythrocyte superoxide dismutase preparation: effects on LPO processes and morphological changes in the viscera of rats with burns under conditions of delayed antishock infusion therapy.
Paramonov BA, Churilova IV, Zinov'ev EV, Chebotarev VY.
PMID: 12660843
4. Administration of superoxide dismutase (24 - 32 mg) in the antishock infusion prevented the development of free radicals and limited organ damage in burn patients.
Bull Exp Biol Med. 2002 Nov;134(5):454-6.
Effect of Erysod (erythrocyte superoxide dismutase) on blood concentration of reactive oxygen species in patients with severe burns and burn shock.
Churilova IV, Zinov'ev EV, Paramonov BA, Drozdova YI, Sidel'nikov VO, Chebotarev
VY.
PMID: 12802450
VITAMIN B3/NIACIN
Animal Study
5. Compared to treatment with saline, treatment with nicotinamide (50 mg twice/day) for 21 days healed burn wounds in rats significantly faster.
J Surg Res. 1989 Nov;47(5):465-9.
The effect of nicotinamide on microvascular density and thermal injury in rats.
Smith YR, Klitzman B, Ellis MN, Kull FC Jr.
PMID: 2530402
VITAMIN C
6. Intravenous treatment with vitamin C (66 mg per kilogram body weight per hour) commenced within 24 hours of injury, reduced fluid requirements, weight gain, swelling and respiratory dysfunction in patients with severe burns to 30 % of their bodies.
Arch Surg. 2000 Mar;135(3):326-31.
Reduction of resuscitation fluid volumes in severely burned patients using ascorbic acid administration: a randomized, prospective study.
PMID: 10722036
Wound Healing
7. Brittle, scarred skin was treated with 4000 mg/day vitamin C which improved wound healing.
J Pediatr. 1978 Mar;92(3):378-84.
Inherited human collagen lysyl hydroxylase deficiency: ascorbic acid response.
Elsas LJ 2nd, Miller RL, Pinnell SR.
PMID: 416188
IRON
8. Iron supplementation (0.5 mg/kilogram body weight per day) was given to a child following burn injury, which normalized blood levels.
An Esp Pediatr. 2002 Jun;56(6):579-81.
[Iron supplementation in a child with severe burns]
Belmonte Torras JA, Tusell Puigbert J, Piera Carreras A, Soler Palacin P, Aulesa
Martinez C, Iglesias Berengue J.
PMID: 12042158
ZINC
9. Patients with venous leg ulcers were treated with zinc oxide gauze (0.4 mg per square centimeter) or placebo for 8 weeks. Those receiving zinc had an 83% success rate compared to the placebo group with 42% success rate.
Br J Dermatol. 1984 Oct;111(4):461-8.
Topical zinc oxide treatment improves arterial and venous leg ulcers.
Stromberg HE, Agren MS.
PMID: 6386033 |
