BRAIN INJURY

CDP CHOLINE
Animal Study

1. Injections of CDP choline (either 200 or 400 mg per kg body weight) prevented neuronal loss and reduced brain damage in rats following a traumatic brain injury.

J Neurosurg. 2003 Apr;98(4):86773.
Cytidinediphosphocholine treatment to decrease traumatic brain injury induced hippocampal neuronal death, cortical contusion volume, and neurological dysfunction in rats.
Dempsey RJ, Raghavendra Rao VL.

SUPEROXIDE DISMUTASE
Animal Study

2. Administration of superoxide dismutase (either 3000 IU or 5000 IU per kilogram body weight) within 1 minute of receiving a brain injury and continued every day for 2 – 3 days prevented neuronal loss following traumatic brain injury in rats.

Surg Neurol. 2003 Mar;59(3):156-60; discussion 160-1. 
Effects of lecithinized superoxide dismutase on neuronal cell loss in CA3 hippocampus after traumatic brain injury in rats.
Yunoki M, Kawauchi M, Ukita N, Sugiura T, Ohmoto T.
PMID: 12681536

ZINC
Animal Study

3. Supplementation with zinc (either 30 mg or 180 mg per kilogram body weight) reduced the degree of neuron cell death in mice with brain injury.

Nutr Neurosci. 2002 Oct;5(5):345-52. 
Moderate zinc deficiency increases cell death after brain injury in the rat.
Yeiser EC, Vanlandingham JW, Levenson CW.
PMID: 12385597