BLOOD DISORDERS
VITAMIN K
(1 microgram = 0.001 milligrams)
1. A single oral dose of vitamin K (1 mg) normalized blood clotting disorders caused by the anticoagulant agent warfarin more quickly than an injected dose vitamin K (1 mg).
Ann Intern Med. 2002 Aug 20;137(4):251-4.
Comment in:
ACP J Club. 2003 Jan-Feb;138(1):10.
Ann Intern Med. 2003 Apr 1;138(7):610-1; author reply 611.
Ann Intern Med. 2003 Apr 1;138(7):610; author reply 611.
Summary for patients in:
Ann Intern Med. 2002 Aug 20;137(4):I39.
Oral Vitamin K lowers the international normalized ratio more rapidly than subcutaneous Vitamin K in the treatment of warfarin-associated coagulopathy. A randomized, controlled trial.
Crowther MA, Douketis JD, Schnurr T, Steidl L, Mera V, Ultori C, Venco A, Ageno W.
PMID: 12186515
2. A daily dose of vitamin K (45 mg/day) improved anemia and increased hemoglobin without side effects in patients with myelodysplastic syndrome (MDS). The researchers recommend vitamin K for MDS patients.
Rinsho Ketsueki. 2002 Feb;43(2):117-21.
[Vitamin K2 therapy for myelodysplastic syndrome]
[Article in Japanese]
Abe Y, Muta K, Hirase N, Choi I, Matsushima T, Hara K, Taguchi F, Suematsu E, Shibata K, Uike N, Nishimura J, Nawata H.
PMID: 11925874
3. A daily dose of vitamin K (45 mg/day) improved anemia and increased hemoglobin without side effects in patients with myelodysplastic syndrome (MDS).
Ann Hematol. 2002 Jan;81(1):16-9. Epub 2001 Dec 08.
Menatetrenone, a Vitamin K2 analog, ameliorates cytopenia in patients with refractory anemia of myelodysplastic syndrome.
Takami A, Asakura H, Nakao S.
PMID: 11807630
4. A daily dose of vitamin K (250 micrograms/day) can protect patients who have a sensitivity to warfarin.
Thromb Haemost. 1999 Mar;81(3):396-9.
Vitamin K intake and sensitivity to warfarin in patients consuming regular diets.
Lubetsky A, Dekel-Stern E, Chetrit A, Lubin F, Halkin H.
PMID: 10102468
5. A single oral dose of vitamin K (1 mg) normalized international normalized ratio (INR) results within 24 hours in patients taking warfarin.
Thromb Haemost. 1998 Jun;79(6):1116-8.
Low-dose oral Vitamin K reliably reverses over-anticoagulation due to warfarin.
Crowther MA, Donovan D, Harrison L, McGinnis J, Ginsberg J.
PMID: 9657434
6. Excessive anticoagulation can be corrected with oral vitamin K (2.5 mg) while withholding 1 or 2 doses of warfarin.
Ann Intern Med. 1997 Jun 15;126(12):959-62.
Correction of excessive anticoagulation with low-dose oral Vitamin K1.
Weibert RT, Le DT, Kayser SR, Rapaport SI.
PMID: 9182473
7. High doses of phytonadione (vitamin K) (200 mg/day) for 5 month were used to normalize clotting in warfarin overdose. There were no side effects with the vitamin K.
Vet Hum Toxicol. 1994 Jun;36(3):216-7.
Symptomatic brodifacoum ingestion requiring high-dose phytonadione therapy.
Sheen SR, Spiller HA, Grossman D.
PMID: 8066968
8. Oral vitamin K (2 mg/day) was effective in normalizing excessive anticoagulation in patients.
Blood Coagul Fibrinolysis. 1993 Oct;4(5):739-41.
Reversal of excessive effect of regular anticoagulation: low oral dose of phytonadione (Vitamin K1) compared with warfarin discontinuation.
Pengo V, Banzato A, Garelli E, Zasso A, Biasiolo A.
PMID: 8292723
9. A dose of vitamin K (0.5 mg) can reverse excessive anticoagulation from warfarin without side effects.
Thromb Haemost. 1992 Jan 23;67(1):13-5.
Effective reversal of warfarin-induced excessive anticoagulation with low dose Vitamin K1.
Shetty HG, Backhouse G, Bentley DP, Routledge PA.
PMID: 1615468
ZINC
10. Children with sickle cell disease may also have zinc deficiency. Children who received 10 mg/day zinc supplement for 12 months had significant increases in height and weight while non-supplemented children had decreases in height and weight scores.
Am J Clin Nutr. 2002 Feb;75(2):300-7.
Comment in:
Am J Clin Nutr. 2002 Feb;75(2):181-2.
Effect of zinc supplementation on growth and body composition in children with sickle cell disease.
Zemel BS, Kawchak DA, Fung EB, Ohene-Frempong K, Stallings VA.
PMID: 11815322 |
