ASTHMA
LYCOPENE
1. Daily doses of lycopene (30 mg/day) reduced exercise-induced asthma (EIA) in patients with EIA.
Allergy. 2000 Dec;55(12):1184-9.
Reduction of exercise-induced asthma oxidative stress by lycopene, a natural antioxidant.
Neuman I, Nahum H, Ben-Amotz A.
N-acetyl L-cysteine (NAC)
Animal Study
2. Daily oral doses of N-acetylcysteine (3 millimoles per kilogram body weight) for one week reduced pulmonary inflammation in rats exposed to antigens to induce asthma.
Eur Respir J. 2003 Mar;21(3):394-400.
Oral N-acetylcysteine attenuates the rat pulmonary inflammatory response to antigen.
Blesa S, Cortijo J, Mata M, Serrano A, Closa D, Santangelo F, Estrela JM, Suchankova J, Morcillo EJ.
Dept of Pharmacology, Faculty of Medicine, University of Valencia, Valencia,
Spain.
VITAMIN B6/PYRIDOXINE
3. Daily doses of pyridoxine (200 mg/day) for 5 months resulted in enhanced tryptophane metabolism, reduced dosage of bronchodilators and cortisone, and a significant improvement in asthma symptoms in children with bronchial asthma.
Ann Allergy. 1975 Aug;35(2):93-7.
Pyridoxine treatment of childhood bronchial asthma.
Collipp PJ, Goldzier S 3rd, Weiss N, Soleymani Y, Snyder R.
PMID: 1096686
PYCNOGENOL
4. Compared to placebo, daily doses of pycnogenol (200 mg/day) for 4 weeks decreased serum leukotrienes and produced a favorable response without side effects in asthmatic patients.
J Med Food. 2001 Winter;4(4):201-209.
Pycnogenol((R)) in the Management of Asthma.
Hosseini S, Pishnamazi S, Sadrzadeh SM, Farid F, Farid R, Watson RR.
SELENIUM
(1 microgram = 0.001 milligrams)
5. Daily doses of selenium (200 micrograms) for 96 weeks resulted in reduced use of inhaled and systemic corticosteroids after 24 and 48 weeks without side effects in asthma patients taking corticosteroids.
Bratisl Lek Listy. 2002;103(1):22-5.
Decreased consumption of corticosteroids after selenium supplementation in corticoid-dependent asthmatics.
Gazdik F, Kadrabova J, Gazdikova K.
PMID: 12061082
6. Compared to placebo, daily doses of selenium (100 micrograms) for 14 weeks improved asthma symptoms in asthmatic patients.
Allergy. 1993 Jan;48(1):30-6.
Selenium supplementation in intrinsic asthma.
Hasselmark L, Malmgren R, Zetterstrom O, Unge G.
PMID: 8457023
VITAMIN B12/COBALAMIN
7. A dose of oral cobalamin (1.5 mg) eliminated asthmatic reaction to metabisulfite in children exposed to the substance.
J Allergy Clin Immunol. 1992 Jul;90(1):103-9.
Asthma with sulfite intolerance in children: a blocking study with cyanocobalamin.
Anibarro B, Caballero T, Garcia-Ara C, Diaz-Pena JM, Ojeda JA.
PMID: 1629495
VITAMIN C/VARIOUS
(1 gram = 1000 milligrams)
8. This review indicates that daily vitamin C (1 – 2 grams/day) may be beneficial for exercise-induced asthma or those with respiratory infections. Daily doses of EPA and DHA fish oil supplements (1 to 1.2 grams/day) may be beneficial to asthmatics. Daily doses of N-acetylcysteine (400 - 1200 mg/day) may be of benefit to patients with Chronic Obstructive Pulmonary Disease.
Prim Care. 2002 Jun;29(2):231-61.
Respiratory and allergic diseases: from upper respiratory tract infections to asthma.
Jaber R.
VITAMIN D
(1 microgram = 0.001 milligrams)
9. Daily doses of vitamin D (0.5-0.75 micrograms/day) relieved pain, lowered risk of broken bones and normalized calcium-phosphorus metabolism in patients with bronchial asthma and osteopenic syndrome.
Ter Arkh. 2002;74(3):32-5.
[Alphacalcidol in the treatment of osteopenic syndrome in patients with bronchial asthma]
[Article in Russian]
Kochetkova EA, Gel'tser BI.
PMID: 11980117
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