ANEMIA
FOLIC ACID
1: Daily doses of ferrous sulfate (350 mg) and folic acid (1.5 mg) for 90 to 100 days is as effective as a tablet of the same dose once/week for 14 weeks at decreasing the incidence of anemia in adolescent girls.
Arch Pediatr Adolesc Med. 2002 Feb;156(2):131-5.
Comment in:
Arch Pediatr Adolesc Med. 2002 Feb;156(2):128-30.
Weekly vs daily iron and folic acid supplementation in adolescent Nepalese girls.
Shah BK, Gupta P.
PMID: 11814373
2: Supplementation with a combination of vitamin A (2.42 mg), ferrous sulfate (120 mg), and folic acid (3.5 mg) significantly decreased anemia (92%), iron deficiency, (90%) and vitamin A deficiency (76%) in adolescent girls.
Am J Clin Nutr. 2001 Jul;74(1):108-15.
Concomitant supplemental vitamin A enhances the response to weekly supplemental iron and folic acid in anemic teenagers in urban Bangladesh.
Ahmed F, Khan MR, Jackson AA.
PMID: 11451725
3: Doses of iron (either 60 or 120 mg) and folic acid (3.5 mg) weekly for 22 weeks relieved iron deficiency and anemia in adolescent girls.
Am J Clin Nutr. 1999 Jun;69(6):1249-56.
School-administered weekly iron-folate supplements improve hemoglobin and ferritin concentrations in Malaysian adolescent girls.
Tee ES, Kandiah M, Awin N, Chong SM, Satgunasingam N, Kamarudin L, Milani S, Dugdale AE, Viteri FE.
PMID: 10357747
VITAMIN B12/COBALAMIN
4: A dose of vitamin B12 (1 mg) every 3 months is sufficient to maintain adequate B 12 levels in perniciuos anemia without side effects.
Scand J Haematol. 1983 Jul;31(1):57-62.
Long term therapy of pernicious anaemia with the depot cobalamin preparation betolvex.
Bastrup-Madsen P, Helleberg-Rasmussen I, Norregaard S, Halver B, Hansen T.
PMID: 6867609
VITAMIN C/ASCORBIC ACID
5. Daily treatment with ascorbic acid (1.7 mg per deciliter) in the dialysate solution improves anemia and reduces Heinz bodies in red blood cells in patients receiving dialysis.
Proc Eur Dial Transplant Assoc. 1977;14:192-9.
Chloramines, an aggravating factor in the anemia of patients on regular dialysis treatment.
Botella J, Traver JA, Sanz-Guajardo D, Torres MT, Sanjuan I, Zabala P.
PMID: 600956
IRON
(1 gram = 1000 milligrams)
6. Daily treatment with iron (80 mg) for 2 months was more effective than iron and zinc (10 mg) combined in improving anemia in infants.
J Nutr. 2003 Apr;133(4):1075-80.
Home-fortification with iron and zinc sprinkles or iron sprinkles alone successfully treats anemia in infants and young children.
Zlotkin S, Arthur P, Schauer C, Antwi KY, Yeung G, Piekarz A.
PMID: 12672922
7. Daily doses of ferrous sulphate (335 mg) and folic acid (500 grams) either weekly or daily for 14 weeks had similar effects on anemia in pregnant women.
Indian Pediatr. 2002 Apr;39(4):339-46.
Comment in:
Indian Pediatr. 2003 Mar;40(3):273; author reply 274.
Impact of daily versus weekly hematinic supplementation on anemia in pregnant women.
Gomber S, Agarwal KN, Mahajan C, Agarwal N.
PMID: 11976463
8. Daily treatment with iron (6 mg per kilogram body weight) for 3 months resulted in lower anemia rates and significantly fewer breath holding spells in children than before treatment.
Arch Dis Child. 1999 Sep;81(3):261-2.
Breath holding spells in 91 children and response to treatment with iron.
Mocan H, Yildiran A, Orhan F, Erduran E.
PMID: 10451402
9. A combination of of vitamin A (200,000 IU), zinc (15 mg) and iron (60 mg) was more effective in treating anemia than iron supplementation alone.
Eur J Clin Nutr. 1999 Feb;53(2):102-6.
Treatment for iron deficiency anaemia with a combined supplementation of iron, vitamin A and zinc in women of Dinajpur, Bangladesh.
Kolsteren P, Rahman SR, Hilderbrand K, Diniz A.
PMID: 10099942
10. Daily iron supplementation (320 mg/twice/day) daily prevented iron deficiency in menstruating women following gastric bypass surgery.
Arch Surg. 1998 Jul;133(7):740-4.
Prophylactic iron supplementation after Roux-en-Y gastric bypass: a prospective, double-blind, randomized study.
Brolin RE, Gorman JH, Gorman RC, Petschenik AJ, Bradley LB, Kenler HA, Cody RP.
PMID: 9688002
11. Pregnant women who could not take oral iron supplements were given 1,000 mg intravenous iron which effectively raised hemoglobin and iron counts.
J Reprod Med. 1997 Feb;42(2):99-103.
Supplementing iron intravenously in pregnancy. A way to avoid blood transfusions.
Hallak M, Sharon AS, Diukman R, Auslender R, Abramovici H.
PMID: 9058345
12. Daily doses of vitamin C (20 mg/day) and iron (30 mg/day) for 2 months increased height and weight, hemoglobin and blood iron levels in anemic school children.
Am J Clin Nutr. 1993 Sep;58(3):339-42.
Decreased rate of stunting among anemic Indonesian preschool children through iron supplementation.
Angeles IT, Schultink WJ, Matulessi P, Gross R, Sastroamidjojo S.
PMID: 8237843
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