ACETAMINOPHEN POISONING
N-acetyl L-cysteine (NAC)
1. Treatment with N-acetylcysteine (140 mg per kilogram of body weight (kbw), then 6 doses of 70 mg per kbw and finally 11 doses of 100 mg per kbw) normalized liver function following ingestion of “2 handfuls” of 650 mg acetaminophen/tablet.
N Engl J Med 1995 Jul 20;333(3):196
Overdose of Extended-Release Acetaminophen
Graudins A, Aaron CK, Linden CH
2. Treatment with intravenous N-acetylcysteine (300 mg per kilogram body weight) every 30 to 60 minutes for 20 hours is necessary for patients at risk for acetaminophen toxicity. This should occur within 10 to 24 hours of ingestion to prevent liver damage.
Journal of the Hong Kong Medical Association (J. HONG KONG MED. ASSOC. )
(Hong Kong) 1994, 46/1 (87-92)
Metabolic activation and paracetamol hepatotoxicity - An update on the management of paracetamol (acetaminophen) poisoning
Chan T.Y.K.; Critchley J.A.J.H.; Chan J.C.N.; Tomlinson B.
Animal Study
3. Treatment with N-acetylcysteine (600 mg per kilogram body weight) was more effective than cimetidine at protecting mice from acetaminophen poisoning. Those receiving N-acetylcysteine had 100% survival while those receiving cimetidine had 68% survival.
Life Sciences ( LIFE SCI. ) (United Kingdom) 1982, 31/1 (31-35)
Cimetidine protects against acetaminophen toxicity
Jackson J.E.
4. Treatment with intravenous N-acetylcysteine (300 mg per kilogram body weight) over 20 hours was effective treatment for acetaminophen poisoning.
Lancet ( LANCET ) (United Kingdom) 1977, 2/8035 (432-434)
Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine
Prescott L.F.; Park J.; Ballantyne A.; et al.
5. Treatment with intravenous N-acetylcysteine (150 mg per kilogram body weight) at 15 minutes, 50 mg per kbw at 4 hours and 100 mg per kbw over the next 16 hours) was effective against acetaminophen poisoning.
European Journal of Clinical Pharmacology ( EUR. J. CLIN. PHARMACOL. ) (Germany) 1989, 37/5 (501-506)
The disposition and kinetics of intravenous N-acetylcysteine in patients with paracetamol overdosage
Prescott L.F.; Donovan J.W.; Jarvie D.R.; Proudfoot A.T. |
